Clinicopathological Characteristics of Low-Grade Appendiceal Mucinous Neoplasm
| Autor: | Tsunekazu Mizushima, Takashi Takeda, Takashi Yao, Kazuhiro Sakamoto, Mitsuo Kishimoto, Kenichi Sugihara, Tetsuya Shiota, Hiroshi Takeyama, Yoshinori Kagawa, Tatsuro Yamaguchi, Toshiya Nagasaki, Kohei Murata, Shingo Noura, Makoto Fujii, Yuko Ohno, Yasumasa Takii, Takeshi Suto |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroenterology Japan Internal medicine medicine Humans Neoplasm Metastasis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Low Grade Appendiceal Mucinous Neoplasm business.industry Cytologic atypia Retrospective cohort study Middle Aged Prognosis Adenocarcinoma Mucinous Survival Analysis Appendiceal neoplasms Appendiceal Neoplasms Case-Control Studies Surgery Female Neoplasm Grading business Cohort study |
| Zdroj: | Digestive surgery. 38(3) |
| ISSN: | 1421-9883 |
| Popis: | Introduction: Recently, “low-grade appendiceal mucinous neoplasms” (LAMNs) have been proposed as one subtype of appendiceal mucinous neoplasms, characterized by a villous or flat proliferation of mucinous epithelium with low-grade cytologic atypia. The aim of this study was to clarify the clinicopathological characteristics of LAMN. Methods: In this multi-institutional cohort study, we retrospectively analyzed the clinicopathological characteristics in appendiceal neoplasms patients who underwent treatment from 2000 to 2017. Results: In total, 922 patients were enrolled, with 279 (30.3%) cases of LAMN, and 93 (10.1%) cases of non-LAMN disease. In comparison with patients with non-LAMN disease, those with LAMN had significantly lower levels of CA19-9 (p = 0.045), a lower frequency of T4 tumors (p < 0.0001), a lower frequency of lymph node metastasis (p < 0.0001), and a lower frequency of distant metastasis (p < 0.0001). Survival analysis revealed that patients with LAMN had a significantly better prognosis than did those with non-LAMN disease (p < 0.001). Among the patients with distant metastasis, those with LAMN had a significantly better prognosis than did those with non-LAMN disease (p = 0.0020), but among the patients without distant metastasis, the difference between the 2 groups was not significant (p = 0.26). However, among patients who underwent complete resection, the difference in prognosis between the 2 groups was not significant (p = 0.10). Conclusions: A multicenter retrospective study revealed that the clinicopathological characteristics of LAMN was different from those of non-LAMN. |
| Databáze: | OpenAIRE |
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