Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
| Autor: | Xiou Cao, Ethan Katznelson, Paul L. Bollyky, Daniel Lazzareschi, Johanna M. Sweere, Swathi Balaji, Jonas D. Van Belleghem, Robert Manasherob, Vivekananda Gupta Sunkari, Dung N. Lam, Patrick R. Secor, Gernot Kaber, Gina A. Suh, Sundeep G. Keswani, Maria Birukova, Payton L. Marshall, Christiaan R. de Vries, Michelle S. Bach, Thomas R. Hawn, Heather D. Ishak, Medeea Popescu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Biology Antibodies Viral Article Microbiology Bacteriophage Mice Immune system Phagocytosis Interferon Immunity medicine Immune Tolerance Animals Humans Pseudomonas Infections Multidisciplinary Innate immune system Tumor Necrosis Factor-alpha biology.organism_classification Type I interferon production Mice Mutant Strains Toll-Like Receptor 3 Mice Inbred C57BL Adaptor Proteins Vesicular Transport TRIF TLR3 Pseudomonas aeruginosa Wound Infection Interferons Pseudomonas Phages medicine.drug |
| Popis: | Phage subverts immune response Pseudomonas aeruginosa ( Pa ) is a multidrug-resistant Gramnegative bacterium commonly found in health care settings. Pa infections frequently result in considerable morbidity and mortality. Sweere et al. found that a type of temperate filamentous bacteriophage that infects and integrates into Pa is associated with chronic human wound infections. Likewise, wounds in mice colonized with phage-infected Pa were more severe and longer-lasting than those colonized by Pa alone. Immune cell uptake of phage-infected Pa resulted in phage RNA production and inappropriate antiviral immune responses, impeding bacterial clearance. Both phage vaccination and transfer of antiphage antibodies were protective against Pa infection. Science , this issue p. eaat9691 |
| Databáze: | OpenAIRE |
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