Unchanged serum adipokine concentrations in the setting of short-term thyroidectomy-induced hypothyroidism
| Autor: | Ayse Kubat Uzum, Ozlem Kaplan, Nese Ozbey, Gungor Uzum, Kezban Nur Planci, Hale Aral, Vahit Tunali, Ozgu Kesmezacar, Ozlem Demir |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Leptin endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Adipokine Body Mass Index Endocrinology Adipokines Hypothyroidism Internal medicine medicine Humans Euthyroid Resistin medicine.diagnostic_test Adiponectin business.industry Body Weight Thyroidectomy nutritional and metabolic diseases General Medicine Middle Aged Lipids Female business Lipid profile Body mass index hormones hormone substitutes and hormone antagonists Follow-Up Studies Goiter Nodular |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 18(6) |
| ISSN: | 1934-2403 |
| Popis: | To investigate short-term effects of thyroidectomy-induced hypothyroidism on leptin, adiponectin, and resistin concentrations in association with anthropometric data.Thirty premenopausal women with euthyroid nodular goiter-mean age, 44.0 ± 11.6 years; mean body mass index (BMI), 28.6 ± 5.9 kg/m2; 13 obese, 7 overweight, and 10 normal weight subjects-scheduled for total thyroidectomy were included in the study. Serum leptin, adiponectin, resistin, free triiodothyronine, free thyroxine, thyroid-stimulating hormone, glucose, insulin, and C-reactive protein concentrations, lipid profile, and anthropometric variables were determined in the euthyroid state (preoperatively) and the hypothyroid state (postoperatively, with a thyroid-stimulating hormone concentration30 mIU/L).Body weight, BMI, waist and hip circumferences, body fat mass, and serum lipid concentrations increased significantly after thyroidectomy. No significant difference was found between preoperative and postoperative serum leptin, adiponectin, and resistin concentrations. Fat tissue mass-corrected leptin, adiponectin, and resistin concentrations did not differ significantly between euthyroid and hypothyroid periods. Thyroid hormone concentrations showed no significant correlations with adipokine levels.Serum adipokine concentrations seem not to change significantly during short-term thyroidectomy-induced hypothyroidism despite significant increases in body weight, BMI, fat mass, and lipid concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|