Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring
| Autor: | Jansen Fernandes, Francisco Romero Cabral, Ricardo Mario Arida, Ana V. Oliveira-Pinto, Glauber Menezes Lopim, Sérgio Gomes da Silva, Alexandre Aparecido de Almeida, Débora Amado Scerni, Roberto Lent |
|---|---|
| Přispěvatelé: | Universidade de Mogi das Cruzes, Universidade de Mogi das Cruces = University of Mogi das Cruzes (UMC), Hospital Israelita Albert Einstein, Universidade Federal de São Paulo (UNIFESP), Universidade Federal do Rio de Janeiro (UFRJ) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Offspring [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Hippocampus lcsh:Medicine Physical exercise Water maze Hippocampal formation Brain-derived neurotrophic factor 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Physical Conditioning Animal [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology medicine Animals Habituation Rats Wistar lcsh:Science Cerebral Cortex Multidisciplinary business.industry lcsh:R brain-derived neurotrophic factor medicine.disease Rats 030104 developmental biology Endocrinology [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis Prenatal Exposure Delayed Effects lcsh:Q Female business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP PLoS ONE PLoS ONE, Public Library of Science, 2016, 11 (1), pp.0147200. ⟨10.1371/journal.pone.0147200⟩ PLoS ONE, Public Library of Science, 2016, 11 (1), pp.e0147200. ⟨10.1371/journal.pone.0147200⟩ PLoS ONE, Vol 11, Iss 1, p e0147200 (2016) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0147200⟩ |
| Popis: | Clinical evidence has shown that physical exercise during pregnancy may alter brain devel- opment and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell num- bers in the hippocampal formation and cerebral cortex of rat pups born from mothers exer- cised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoid- ance task). Results showed that maternal exercise during pregnancy increased BDNF lev- els and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exer- cise during pregnancy enhances offspring cognitive function (habituation behavior and spa- tial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Clinical evidence has shown that physical exercise during pregnancy may alter brain devel- opment and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell num- bers in the hippocampal formation and cerebral cortex of rat pups born from mothers exer- cised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoid- ance task). Results showed that maternal exercise during pregnancy increased BDNF lev- els and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exer- cise during pregnancy enhances offspring cognitive function (habituation behavior and spa- tial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring. FAPESP: 09/06953-4 FAPESP: 10/11353-3 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|