Pathological responses after angiogenesis or EGFR inhibitors in metastatic colorectal cancer depend on the chemotherapy backbone
| Autor: | Catherine Hubert, Javier Carrasco, M. Van den Eynde, Anne Jouret-Mourin, J-L Canon, Etienne Danse, J-F Gigot, B. Navez, X Chapaux, Marco Gizzi, Christine Sempoux, Géraldine Pairet, P. Lefesvre, Yves Humblet, N Tinton, Valérie Lannoy |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Disease free survival Organoplatinum Compounds Angiogenesis Colorectal cancer medicine.medical_treatment colorectal cancer Antineoplastic Agents Irinotecan Disease-Free Survival Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pathological EGFR inhibitors Aged Retrospective Studies Aged 80 and over Chemotherapy Neovascularization Pathologic business.industry Retrospective cohort study surgical resection Middle Aged medicine.disease targeted therapy ErbB Receptors Oxaliplatin Camptothecin Female business Translational Therapeutics Colorectal Neoplasms pathological response liver metastases medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Optimal preoperative treatment before colorectal cancer metastases (CRCM) resection remains unclear. This study evaluated pathological responses (pR) in CRCM resected after chemotherapy alone or combined with angiogenesis or epidermal growth factor receptor (EGFR) inhibitors. Methods: Pathological response was retrospectively evaluated on 264 resected metastases from 99 patients. The proportion of responding metastases after different preoperative treatments was reported and compared. Patient's progression-free survival (PFS) and overall survival (OS) were compared based on pR. Results: The combination of anti-angiogenics with oxaliplatin-based chemotherapy resulted in more pR than when they were combined with irinotecan-based chemotherapy (80% vs 50% P |
| Databáze: | OpenAIRE |
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