Cancer incidence in a cohort of asbestos-exposed workers undergoing health surveillance
| Autor: | Federica Edith Pisa, Massimo Bovenzi, Fabiano Barbiero, Fabio Barbone, Corrado Negro, Valentina Rosolen, Anica Casetta, Manuela Giangreco, Tina Zanin |
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| Přispěvatelé: | Barbiero, F, Zanin, T, Pisa, Fe, Casetta, A, Rosolen, V, Giangreco, M, Negro, C, Bovenzi, M, Barbone, F |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Mesothelioma medicine.medical_specialty Lung Neoplasms cancer incidence Population epidemiology Monfalcone medicine.disease_cause Asbestos Cohort Studies asbesto 03 medical and health sciences 0302 clinical medicine asbestos shipbuilding Neoplasms Occupational Exposure Internal medicine medicine Humans 030212 general & internal medicine Lung cancer education Aged Cancer incidence Epidemiology Monfalcone Shipbuilding Public Health Environmental and Occupational Health education.field_of_study business.industry Incidence Incidence (epidemiology) Mesothelioma Malignant Environmental and Occupational Health Cancer Middle Aged medicine.disease Occupational Diseases Italy Population Surveillance 030220 oncology & carcinogenesis Relative risk Cohort epidemiology Public Health business |
| Popis: | Objectives. To compare a local cohort of 2,488 men occupationally exposed to asbestos and enrolled in a public health surveillance program with the 1995 – 2009 cancer incidence of the general population of Friuli Venezia Giulia (FVG) region, Northeast Italy, we conducted a historical cohort study. Methods. Standardized incidence ratios (SIRs), with 95% confidence interval (95%CI), for specific cancer sites were estimated in the cohort and in subgroups of workers employed in shipbuilding between 1974-1994. For internal comparisons, we estimated incidence rate ratios (IRRs) for all cancers, lung cancer and mesothelioma, by level of exposure to asbestos and sector of employment adjusted for smoking habits and age at start of follow-up. Results. Among cohort members the SIR was 8.82 (95%CI 5.95-12.61) for mesothelioma and 1.61 (95%CI 1.26-2.04) for lung cancer. In subgroup analyses, the SIR for lung cancer in subjects hired in shipbuilding between 1974-1984 was 2.09 (95%CI 1.32-3.13). In the overall cohort, a borderline increased incidence was also found for stomach cancer (SIR=1.53 95%CI 0.96-2.31). Internal comparisons within the cohort show that among men with high asbestos exposure level the relative risk was almost three-fold for lung cancer (IRR=2.94 95%CI 1.01-8.57). Conclusions. This cohort experienced an excess in the incidence of both mesothelioma and lung cancer, showing increasing incidence rates at higher level of asbestos exposure. For lung cancer, the relative incidence was highest among workers hired in shipbuilding between 1974-1984. |
| Databáze: | OpenAIRE |
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