Fibrosis and cancer: A strained relationship
| Autor: | Valerie M. Weaver, Bram Piersma, Mary-Kate Hayward |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Angiogenesis Cell Transformation Malignant transformation Extracellular matrix 0302 clinical medicine Cancer-Associated Fibroblasts Fibrosis Antineoplastic Combined Chemotherapy Protocols Tumor Microenvironment 2.1 Biological and endogenous factors Breast CAF Aetiology Cancer Clinical Trials as Topic Prognosis Progression-Free Survival Extracellular Matrix Cell Transformation Neoplastic Treatment Outcome Oncology Pancreatic Ductal 030220 oncology & carcinogenesis Female Carcinoma Pancreatic Ductal Epithelial-Mesenchymal Transition Stromal cell Oncology and Carcinogenesis Breast Neoplasms Article Pancreatic Cancer 03 medical and health sciences Rare Diseases Stroma Breast Cancer Genetics medicine Humans Mechanoreciprocity Oncology & Carcinogenesis Pancreas Neoplastic ECM business.industry Carcinoma Mesenchymal stem cell medicine.disease Pancreatic Neoplasms 030104 developmental biology Cancer research Tumor Escape Digestive Diseases business |
| Zdroj: | Biochimica et biophysica acta. Reviews on cancer, vol 1873, iss 2 Biochim Biophys Acta Rev Cancer |
| ISSN: | 0304-419X |
| DOI: | 10.1016/j.bbcan.2020.188356 |
| Popis: | Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and drives a mesenchymal transition. A stiff ECM also induces angiogenesis, hypoxia and compromises anti-tumor immunity. Not surprisingly, tumor aggression and poor patient prognosis correlate with degree of tissue fibrosis and level of stromal stiffness. In this review, we discuss the reciprocal interplay between tumor cells, cancer associated fibroblasts (CAF), immune cells and ECM stiffness in malignant transformation and cancer aggression. We discuss CAF heterogeneity and describe its impact on tumor development and aggression focusing on the role of CAFs in engineering the fibrotic tumor stroma and tuning tumor cell tension and modulating the immune response. To illustrate the role of mechanoreciprocity in tumor evolution we summarize data from breast cancer and pancreatic ductal carcinoma (PDAC) studies, and finish by discussing emerging anti-fibrotic strategies aimed at treating cancer. |
| Databáze: | OpenAIRE |
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