Diabetes and endogenous orphanin FQ/nociceptin levels in rat CSF and plasma

Autor:	Melinda Gyenge, B Borbála Bizderi, M Mónika Hantos, Valéria Kecskeméti, Kornélia Tekes
Rok vydání:	2005
Předmět:	medicine.medical_specialty Every Two Weeks business.industry Endocrinology Diabetes and Metabolism Endogeny Radioimmunoassay medicine.disease Nociceptin receptor Endocrinology Ageing Internal medicine Diabetes mellitus Neuropathic pain Orphanin FQ Internal Medicine Medicine business
Zdroj:	Scopus-Elsevier
ISSN:	2073-5944 1606-7754
Popis:	It is widely accepted that OFQ/N is involved in the metabolic neuropathic pain caused by diabetes mellitus. In our present study we aimed to determine whether long-term diabetes characterized by hyperglycaemia has any effect on endogenous OFQ/N levels. Diabetes was initiated in 8 -week old male Wistar rats by intravenous administration of strepto zotocin (60mg/kg body weight). Body weight and blood glucose levels were measured weekly and OrphaninFQ/nociceptin (OFQ/N) levels were determined by radioimmunoassay every two weeks between 2 to 16 weeks of the diabetic period. Neither plasma nor CSF OFQ/N levels showed significant difference from control in long-term diabetic rats. Age-dependence of both plasma and CSF OFQ/N levels reached the adult level in 3 -month old rats. It is concluded that the metabolic neuropathic pain observed in streptozotocin-induced experimental diabetes is not related to changes in plasma or CSF levels of endogenous OFQ/N. (Int J Diabetes Metab 13: 147-153, 2005)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e508443bbd4b425effb1ab149c024d https://doi.org/10.1159/000497583 Zobrazit plný text záznamu