Radical Gastrectomy After Chemotherapy May Prolong Survival in Stage IV Gastric Cancer: A Korean Multi-institutional Analysis
| Autor: | Han Mo Yoo, Eun Young Kim, Ho Seok Seo, Han Hong Lee, Jun Hyun Lee, Wook Kim, Sung Keun Kim, Kyo Young Song, Jin-Jo Kim, Kyung Hwa Chun, Chang-Hyun Kim, Hyung Min Chin, Seung Man Park, Yoon Ju Jung, Hae Myung Jeon, Jeong Goo Kim, Dong Jin Kim, Cho Hyun Park |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Palliative care medicine.medical_treatment Gastroenterology 03 medical and health sciences 0302 clinical medicine Gastrectomy Stomach Neoplasms Internal medicine medicine Humans Survival rate Aged Neoplasm Staging Chemotherapy business.industry Palliative Care Cancer Vascular surgery Middle Aged medicine.disease Prognosis Combined Modality Therapy Survival Rate Cardiothoracic surgery 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Female business Abdominal surgery |
| Zdroj: | World journal of surgery. 42(10) |
| ISSN: | 1432-2323 |
| Popis: | BACKGROUND: Despite the development of newer treatments, the prognosis for patients with stage IV gastric cancer remains grave. This study evaluated the efficacy of gastrectomy following response to chemotherapy in patients with stage IV gastric cancer.A total of 419 patients who were diagnosed with stage IV gastric cancer were identified from the multi-institutional Catholic Gastric Cancer Study Group database. The patients were divided into four groups: 212 were in the chemotherapy only (CTx) group, 124 were in the chemotherapy after palliative gastrectomy (G-CTx) group, 23 were in the radical gastrectomy after chemotherapy (CTx-G) group, and 60 were in the best supportive care group. To compensate for the effects of chemotherapy, cases of chemotherapy responsive were analyzed separately. To identify factors affecting survival rates, cure rates for surgery in the surgery group were analyzed.The 3-year survival rate of the CTx-G group was significantly higher than that of the CTx group (42.8 vs. 12.0%, p = 0.001). Moreover, the CTx-G group's 3-year survival rate was greater than that of the G-CTx group (42.8 vs. 37.1%, p = 0.207). Chemotherapy-responsive patients in the CTx-G group had a better 3-year survival rate than those in the G-CTx group (46.1 vs. 18.4%, respectively, p = 0.011). In the surgery group, R0 resection led to a significantly better 3-year survival rate than palliative gastrectomy (61.1 vs. 16.2%, p = 0.003).Adjuvant surgery might improve the survival rate of patients with stage IV gastric cancer, particularly in R0 resection cases. |
| Databáze: | OpenAIRE |
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