One leg standing time predicts fracture risk in older women independent of clinical risk factors and BMD
| Autor: | Nicholas C. Harvey, Helena Johansson, Dan Mellström, Eugene V. McCloskey, J. A. Kanis, Mattias Lorentzon, B. Larsson, Liesbeth Vandenput, Daniel Sundh, Linda Johansson, Kristian F. Axelsson, Enwu Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
The one leg standing test Epidemiology Fracture risk Endocrinology Diabetes and Metabolism Clinical risk factors and bone mineral density Population Osteoporosis Absorptiometry Photon Bone Density Risk Factors medicine Humans education Aged Bone mineral Aged 80 and over education.field_of_study Hip fracture Leg Proportional hazards model business.industry Hip Fractures medicine.disease Confidence interval Orthopedic surgery Physical therapy Female Original Article business Osteoporotic Fractures |
| Zdroj: | Osteoporosis International |
| ISSN: | 0937-941X |
| Popis: | Summary In women of ages 75–80 years, a low one leg standing time (OLST) was associated with an increased risk of incident fractures, independently of bone mineral density and clinical risk factors. OLST contributed substantially to fracture probability, indicating that the test should be considered when evaluating fracture risk in older women. Introduction Physical function and risk of falls are important risk factors for fracture. A few previous studies have suggested that a one leg standing time (OLST) less than 10 s predicts fracture risk, but the impact of OLST, in addition to known clinical risk factors, for fracture probability is unknown. The aim of this study was to determine the independent contribution of OLST to fracture probability in older women. Methods The Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone Fractures (SUPERB) is a prospective population-based study of 3028 women 75–80 years old, recruited from the greater Gothenburg area in Sweden. At baseline, information on risk factors was collected using questionnaires, bone mineral density was measured with dual-energy X-ray absorptiometry (DXA), and OLST was performed. Results During a median follow-up of 3.6 years (IQR 1.5 years), X-ray-verified incident fractures were identified using health records. OLST was available in 2405 women. OLST less than 10 s was associated with an increased risk for incident hip fracture (Hazard Ratio (HR) 3.02, 95% Confidence Interval (CI) [1.49–6.10]), major osteoporotic fracture (HR 95% CI 1.76 [1.34–1.46]), and nonvertebral fracture (HR 95% CI 1.61 [1.26–2.05]) in Cox regression analyses adjusted for age, height, and weight. Depending on BMD, the 4-year fracture probability increased by a factor of 1.3 to 1.5 in a 75-year-old woman with a low OLST ( |
| Databáze: | OpenAIRE |
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