Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment: a randomised controlled study
| Autor: | Marcel G. M. Olde Rikkert, Emer Guinan, Brian A. Lawlor, Stefan Schneider, Bibiana C Mota, Áine M. Kelly, Cathal Walsh, Kate E. Devenney |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] brain Population Physical Therapy Sports Therapy and Rehabilitation 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine R5-920 blood Internal medicine medicine Aerobic exercise 0501 psychology and cognitive sciences Orthopedics and Sports Medicine Effects of sleep deprivation on cognitive performance Exercise physiology education exercise physiology Brain-derived neurotrophic factor education.field_of_study exercise business.industry 05 social sciences Cognition Ageing ageing Original Article business 030217 neurology & neurosurgery Blood sampling |
| Zdroj: | BMJ Open Sport — Exercise Medicine BMJ Open Sport & Exercise Medicine, Vol 5, Iss 1 (2019) BMJ Open Sport & Exercise Medicine, 5, e000499 BMJ Open Sport & Exercise Medicine, 5, 1, pp. e000499 |
| ISSN: | 2055-7647 |
| Popis: | ObjectiveTo investigate the brain-derived neurotrophic factor (BDNF) and cognitive response to a short bout of high-intensity aerobic exercise in older adults with mild cognitive impairment (MCI).MethodsParticipants were randomised to one of two testing schedules, completing either a standardised exercise test (group A) or a resting control condition (group B). Blood sampling and cognitive measures (visuospatial learning and memory, sustained attention and executive function) were collected at baseline (T1) and postintervention (T2). An additional measurement of study outcomes was collected after exercise (T3) in group B only.Results64 participants (female 53.2%, mean age 70.5±6.3 years) with MCI were recruited. From T1 to T2, serum BDNF (sBDNF) concentration increased in group A (n=35) (median (Md) 4564.61±IQR 5737.23 pg/mL to Md 5173.27±5997.54 pg/mL) and decreased in group B (Md 4593.74±9558.29 pg/mL to Md 3974.66±3668.22 pg/mL) (between-group difference p=0.024, effect size r=0.3). The control group made fewer errors on the sustained attention task compared with the exercise group (p=0.025). Measures of visuospatial learning and memory or executive function did not change significantly between groups.ConclusionThis study is the first to show that a short bout of high-intensity aerobic exercise increases peripheral sBDNF in a population with MCI. However, acute exercise did not improve cognitive performance. |
| Databáze: | OpenAIRE |
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