Insights Into the Physiology of C-peptide
| Autor: | Marketa Vankova, Běla Bendlová, P Lukasova, Josef Vcelak, D Vejrazkova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Physiology medicine.medical_treatment Bioactive molecules 030209 endocrinology & metabolism Review Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Humans Vascular Diseases C-Peptide C-peptide Mechanism (biology) Insulin Late type General Medicine Human physiology 030104 developmental biology Diabetes Mellitus Type 2 chemistry Mechanism of action Metabolic effects Insulin Resistance Nervous System Diseases medicine.symptom |
| Zdroj: | Physiol Res |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.934519 |
| Popis: | Current knowledge suggests a complex role of C-peptide in human physiology, but its mechanism of action is only partially understood. The effects of C-peptide appear to be variable depending on the target tissue, physiological environment, its combination with other bioactive molecules such as insulin, or depending on its concentration. It is apparent that C-peptide has therapeutic potential for the treatment of vascular and nervous damage caused by type 1 or late type 2 diabetes mellitus. The question remains whether the effect is mediated by the receptor, the existence of which is still uncertain, or whether an alternative non-receptor-mediated mechanism is responsible. The Institute of Endocrinology in Prague has been paying much attention to the issue of C-peptide and its metabolic effect since the 1980s. The RIA methodology of human C-peptide determination was introduced here and transferred to commercial production. By long-term monitoring of C-peptide oGTT-derived indices, the Institute has contributed to elucidating the pathophysiology of glucose tolerance disorders. This review summarizes the current knowledge of C-peptide physiology and highlights the contributions of the Institute of Endocrinology to this issue. |
| Databáze: | OpenAIRE |
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