Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease
| Autor: | Ying Xia, Vincent Dore, Victor L. Villemagne, Brendan S. Silbert, Jurgen Fripp, James D. Doecke, Elise J Harrison, Adrian Kamer, Robert Grenfell, Madeline Peretti, Simon McBride, Christopher C. Rowe, Paul Maruff, Lidija Milicic, Kelly K. Pertile, Steven J. Collins, Tania Taddei, Christine Thai, Andrea G. Louey, Michael Weinborn, Richard Head, Pierrick Bourgeat, Colin L. Masters, Olivier Salvado, Sabine Bird, S. Lance Macaulay, Rebecca L. Rumble, Michael Vacher, Simon Gibson, Lucy Lim, Amir Fazlollahi, Samantha C. Burnham, Kathryn A. Ellis, Yen Ying Lim, Regan Tyrrell, Julia Bomke, Michael Woodward, Belinda M. Brown, Joanne Robertson, Brett Trounson, Simon M. Laws, Carolyn Chadunow, Magdalene Soh, Liang Jin, Morgan Radler, Greg Savage, Christopher Fowler, Ralph N. Martins, Samantha L. Gardener, Fiona Lamb, Mark Rodrigues, Lucy Mackintosh, David Ames, Stephanie R. Rainey-Smith, Lis Evered, Alan Rembach, Tenielle Porter, Qiao-Xin Li, Nicola T. Lautenschlager, Shiji Varghese, Ashley I. Bush, Hamid R. Sohrabi, Kevin Taddei |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Gerontology Research Report cognition Aβ-amyloid imaging lifestyle Disease 03 medical and health sciences 0302 clinical medicine mild cognitive impairment Neuroimaging medicine cohort study preclinical Alzheimer’s disease Dementia Prospective cohort study business.industry General Neuroscience prodromal Alzheimer’s disease biomarkers Cognition medicine.disease Cognitive test Psychiatry and Mental health Clinical Psychology 030104 developmental biology Cohort observational longitudinal Geriatrics and Gerontology business Alzheimer’s disease 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Journal of Alzheimer's Disease Reports |
| ISSN: | 2542-4823 |
| Popis: | Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s disease dementia (AD)) as an ‘Inception cohort’ who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an ‘Enrichment cohort’ (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations. Results: AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression. Conclusion: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims. |
| Databáze: | OpenAIRE |
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