Associations of Serum Cytokines and Chemokines with the Risk of Incident Cancer in a Prospective Rheumatoid Arthritis Cohort
| Autor: | Gail S. Kerr, Jeremy Sokolove, Andreas M. Reimold, Harlan Sayles, Joshua F. Baker, William H. Robinson, Ted R. Mikuls, Grant W. Cannon, Apar Kishor Ganti, Brian C. Sauer, Megan Campany, Geoffrey M. Thiele, Punyasha Roul, Bryant R. England, Yangyuna Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Chemokine medicine.medical_treatment Immunology Risk Assessment Article Chemokine Measurement Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Neoplasms Immunology and Allergy Medicine Humans Prospective Studies Registries Lung cancer Aged Veterans Pharmacology Cancer prevention biology Proportional hazards model business.industry Incidence Cancer Middle Aged medicine.disease United States United States Department of Veterans Affairs 030104 developmental biology Cytokine 030220 oncology & carcinogenesis Rheumatoid arthritis Antirheumatic Agents biology.protein Cytokines Female business Follow-Up Studies |
| Zdroj: | Int Immunopharmacol |
| Popis: | OBJECTIVES: We aimed to assess whether serum cytokine/chemokine concentrations predict incident cancer in RA patients. METHODS: Data from cancer-free enrollees in the Veterans Affairs Rheumatoid Arthritis (VARA) Registry were linked to a national VA oncology database and the National Death Index (NDI) to identify incident cancers. Seventeen serum cytokines/chemokines were measured from enrollment serum and an overall weighted cytokine/chemokine score (CK score) was calculated. Associations of cytokines/chemokines with all-site, lung, and lymphoproliferative cancers were assessed in Cox regression models accounting for relevant covariates including age, sex, RA disease activity, and smoking. RESULTS: In 1,216 patients, 146 incident cancers (42 lung and 23 lymphoproliferative cancers) occurred over 10,072 patient-years of follow-up with a median time of 4.6 years from enrollment (cytokine/chemokine measurement) to cancer incidence. In fully adjusted models, CK score was associated with a higher risk of all-site (aHR 1.32, 95% CI 1.01-1.71, p |
| Databáze: | OpenAIRE |
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