Clinicopathological study of gall bladder carcinoma with special reference to gallstones: our 8-year experience from eastern India
| Autor: | Sumit Chaudhuri, Ramesh Aggarwalla, Sumyra Khurshid Qadri, Sarfaraz Jalil Baig, Vishnu Kumar Bhartia, N.K. Pal, Nissar Hussain Hamdani, Sanjay Debakshi |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Abdominal pain Time Factors Epidemiology medicine.medical_treatment India Gallstones Adenocarcinoma Gastroenterology Internal medicine medicine Carcinoma Humans Cholecystectomy Prospective Studies Prospective cohort study Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry General surgery Incidence (epidemiology) Gallbladder Public Health Environmental and Occupational Health Middle Aged medicine.disease Prognosis medicine.anatomical_structure Oncology Female Gallbladder Neoplasms medicine.symptom business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 13(11) |
| ISSN: | 2476-762X |
| Popis: | Gallbladder carcinoma (GBC) is the commonest cancer of the biliary tree and the most frequent cause of death from biliary malignancies. The incidence of GBC shows prominent geographic, age, race, and gender-related differences and is 4-7 times higher in patients with gallstones. This prompted us to study the clinicopathological aspects of the disease and the incidence of gallstones in gallbladder carcinoma patients, in this part of India. In this, combined retrospective (Jan 2004-March 2010) and prospective study (April 2010-Dec 2011) of eight years, 198 patients of gallbladder carcinoma (50 males and 148 females), (range 28-82 years; mean 55 years) were studied. Most of the patients were poor and presented with abdominal pain and mass, with abnormal lab parameters. Gallstones were present in 86% of patients. Surgical exploration was performed in 130, with gallbladder resection in 60 (including 7 incidental GBC). Adenocarcinoma (87.7%) was the commonest histological type. The study indicates that GBC is common in our scenario. It is a disease of elderly females, has a strong association with gallstones and every cholecystectomy specimen should be examined histopathologically. |
| Databáze: | OpenAIRE |
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