Expression and function of nicotinic acetylcholine receptors in stem cells
| Autor: | Carlos M. Carballosa, Herman S. Cheung, Jordan M. Greenberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
lcsh:Medical technology
regeneration potential lcsh:Biotechnology nAChR stem cells lcsh:TP248.13-248.65 Muscarinic acetylcholine receptor medicine nicotinic acetylcholine receptor lcsh:Chemical engineering Acetylcholine receptor Chemistry lcsh:TP155-156 multipotent stem cells Cell biology Endothelial stem cell Nicotinic acetylcholine receptor differentiation potential Nicotinic agonist lcsh:R855-855.5 Stem cell pluripotent stem cells Neuroscience Acetylcholine medicine.drug Adult stem cell nicotine |
| Zdroj: | AIMS Bioengineering, Vol 3, Iss 3, Pp 245-263 (2016) |
| ISSN: | 2375-1495 |
| Popis: | Nicotinic acetylcholine receptors are prototypical ligand gated ion channels typically found in muscular and neuronal tissues. Functional nicotinic acetylcholine receptors, however, have also recently been identified on other cell types, including stem cells. Activation of these receptors by the binding of agonists like choline, acetylcholine, or nicotine has been implicated in many cellular changes. In regards to stem cell function, nicotinic acetylcholine receptor activation leads to changes in stem cell proliferation, migration and differentiation potential. In this review we summarize the expression and function of known nicotinic acetylcholine receptors in different classes of stem cells including: pluripotent stem cells, mesenchymal stem cells, periodontal ligament derived stem cells, and neural progenitor cells and discuss the potential downstream effects of receptor activation on stem cell function. |
| Databáze: | OpenAIRE |
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