Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies
| Autor: | Irene Rebelo, Alice Santos-Silva, Luís Pereira-Leite, Luís Belo, Dairena Gaffney, Muriel J. Caslake, Alexandre Quintanilha |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Apolipoprotein B Pregnancy Trimester Third Preeclampsia chemistry.chemical_compound High-density lipoprotein Pre-Eclampsia Pregnancy Reference Values Internal medicine medicine Humans Particle Size Triglycerides reproductive and urinary physiology Apolipoproteins B Apolipoprotein A-I medicine.diagnostic_test biology Triglyceride business.industry Cholesterol Cholesterol HDL Osmolar Concentration Postpartum Period Cholesterol LDL medicine.disease Cross-Sectional Studies Endocrinology chemistry Low-density lipoprotein biology.protein Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Lipid profile business Postpartum period |
| Zdroj: | Atherosclerosis. 162:425-432 |
| ISSN: | 0021-9150 |
| Popis: | The aim of this study was to evaluate changes in lipids, apolipoproteins and lipoproteins in Portuguese pregnant women and their potential involvement in the pathophysiology of preeclampsia. A cross-sectional study was performed by collecting blood samples in the first (n=64), second (n=48) and third (n=67) trimesters and puerperium (n=32) of normal pregnancies. Samples from preeclamptic women were obtained in the third trimester (n=51) and in puerperium (n=26). As normal pregnancy progressed and triglyceride (TG) levels rose there was a decrease in low density lipoprotein (LDL) size, as measured by peak and mean particle diameter (MPD), with an increased proportion of atherogenic small dense LDL. Preeclamptic women exhibited, in the third trimester and puerperium, higher mean serum TG concentration and lower high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) levels compared with healthy pregnant women. In the third trimester, LDL-mean particle diameter (LDL-MPD) and LDL cholesterol-apolipoprotein B (LDLc-apo B) ratio were also significantly reduced in the pathologic group. We conclude that human gestation is associated with an 'atherogenic' lipid profile that is further enhanced in preeclampsia and that this profile may be a potential contributor to endothelial cell dysfunction. |
| Databáze: | OpenAIRE |
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