| Autor: |
Joseph J. Eron, William C. Mathews, Mari M. Kitahata, Susan R. Heckbert, Lisa Rosenblatt, Heidi M. Crane, Richard D. Moore, Felicia C. Chow, Joseph R. Zunt, Andrew Huffer, Robin M. Nance, David L. Tirschwell, H. Nina Kim, Joseph A.C. Delaney, Corey Ritchings, Elvin Geng, Peter W. Hunt, Greer A. Burkholder, Emily L. Ho, Michael S. Saag, Rizwan Kalani, Matthew J. Budoff, Bridget M. Whitney, Kyra J. Becker, Daniel R. Drozd, Brian R. Wood |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of acquired immune deficiency syndromes (1999), vol 81, iss 5 |
| Popis: |
Objective: Bilirubin is an antioxidant that may suppress lipid oxidation. Elevated bilirubin is associated with decreased cardiovascular events in HIV-uninfected populations. We examined these associations in people living with HIV (PLWH). Methods: Potential myocardial infarctions (MIs) and strokes were centrally adjudicated. We examined MI types: type 1 MI (T1MI) from atherosclerotic plaque instability and type 2 MI (T2MI) in the setting of oxygen demand/supply mismatch such as sepsis. We used multivariable Cox regression analyses to determine associations between total bilirubin levels and outcomes adjusting for traditional and HIV-specific risk factors. To minimize confounding by hepatobiliary disease, we conducted analyses limited to bilirubin values |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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