Donor-specific antibodies, glomerulitis, and human leukocyte antigen B eplet mismatch are risk factors for peritubular capillary C4d deposition in renal allografts
| Autor: | Jin Zheng, Hui Guo, Hui-Lin Gong, Ping Lan, Chen-Guang Ding, Yang Li, Xiao-Ming Ding, Wu-Jun Xue, Yuan-Yuan Ji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
medicine.medical_specialty human leukocyte antigen eplet endocrine system diseases Biopsy Human leukocyte antigen Gastroenterology HLA Antigens Risk Factors Internal medicine Complement C4b medicine Humans Kidney transplantation Retrospective Studies Univariate analysis Proteinuria medicine.diagnostic_test business.industry Original Articles General Medicine Odds ratio Allografts medicine.disease Kidney Transplantation donor-specific antibody Peptide Fragments HLA-B Glomerulitis Transplantation HLA-B Antigens C4d deposition Medicine medicine.symptom business |
| Zdroj: | Chinese Medical Journal, Vol 134, Iss 23, Pp 2874-2881 (2021) Chinese Medical Journal |
| ISSN: | 2542-5641 0366-6999 |
| DOI: | 10.1097/CM9.0000000000001685 |
| Popis: | Background:. The complement system plays an important role in the immune response to transplantation, and the diagnostic significance of peritubular capillary (PTC) C4d deposition (C4d+) in grafts is controversial. The study aimed to fully investigate the risk factors for PTC C4d+ and analyze its significance in biopsy pathology of kidney transplantation. Methods:. This retrospective study included 124 cases of kidney transplant with graft biopsy and donor-specific antibody (DSA) testing from January 2017 to December 2019 in a single center. The effects of recipient pathological indicators, eplet mismatch (MM), and DSAs on PTC C4d+ were examined using univariate and multivariate logistic regression analyses. Results:. In total, 35/124 (28%) were PTC C4d+, including 21 with antibody-mediated rejection (AMR), eight with renal tubular injury, three with T cell-mediated rejection, one with glomerular disease, and two others. Univariate analysis revealed that DSAs (P |
| Databáze: | OpenAIRE |
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