Use of spectral tracking technique to evaluate the changes in left ventricular function in patients undergoing chemotherapy for colorectal cancer

Autor: Lei Huang, Guilin Lu, Zhong Wang, Xueting Guo, Zhen Wang, Caiyun Zhang, Zijing Zhai, Jia Feng, Kuican Liu, Wenjuan Qin, Shanshan Dong
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Time Factors
Heart Diseases
Colorectal cancer
medicine.medical_treatment
Leucovorin
030204 cardiovascular system & hematology
Ventricular Function
Left
03 medical and health sciences
0302 clinical medicine
Troponin complex
Predictive Value of Tests
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Radiology
Nuclear Medicine and imaging
In patient
Echocardiography
Four-Dimensional
Cardiac imaging
Chemotherapy
Ejection fraction
Receiver operating characteristic
business.industry
Middle Aged
medicine.disease
Cardiotoxicity
Echocardiography
Doppler
Biomechanical Phenomena
Oxaliplatin
Early Diagnosis
medicine.anatomical_structure
Ventricle
030220 oncology & carcinogenesis
Cardiology
Female
Fluorouracil
Colorectal Neoplasms
Cardiology and Cardiovascular Medicine
business
Zdroj: The International Journal of Cardiovascular Imaging. 37:1203-1213
ISSN: 1573-0743
1569-5794
DOI: 10.1007/s10554-020-02103-0
Popis: To evaluate the changes in left ventricular myocardial function in patients with colorectal cancer undergoing chemotherapy with mFOLFOX6 (oxaliplatin + 5-fluorouracil + calcium folinate) using three-dimensional speckle-tracking echocardiography (3D-STE). Data were collected from 30 patients diagnosed with colorectal cancer in our hospital treated with mFOLFOX6. We used 3D-STE to measure the following parameters of left ventricle function: global longitudinal strain (GLS), global area strain (GAS), global circumferential strain (GCS), global radial strain (GRS), and left ventricular twist (LVtw). Myocardial composite index (MCI) was calculated from measured values (MCI = GLS × LVtw). The above listed parameters were compared before and after chemotherapy. Receiver operating curves (ROC) were prepared for each parameter and analyzed to identify correlations among MCI, LVEF, GLS, and cTnT. Compared with the pre-chemotherapy state, the absolute values of MCI, LVtw, GLS, GAS, GCS, and GRS decreased with increasing cumulative doses of chemotherapeutic drugs. The absolute values of GAS, GLS, MCI, and LVtw decreased after the first cycle of chemotherapy (P
Databáze: OpenAIRE
Externí odkaz: