The overnight reduction of amyloid β 1-42 plasma levels is diminished by the extent of sleep fragmentation, sAPP-β, and APOE ε4 in psychiatrists on call
| Autor: | Timo Grimmer, Bastian Fatke, Marion Ortner, Alexander Kurz, Sandra Lüscher, Alexander Hapfelmeier, Hans Förstl, Anna-Mareike Parchmann, Dirk Schwerthöffer, Michael Rentrop, Felix Müller-Sarnowski, Oliver Goldhardt, Theresa Laub, Patricia Hölzle, Panagiotis Alexopoulos, Tamara Eisele |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Amyloid β Amyloid Epidemiology Apolipoprotein E4 03 medical and health sciences Cellular and Molecular Neuroscience Amyloid beta-Protein Precursor 0302 clinical medicine Developmental Neuroscience Alzheimer Disease Internal medicine medicine Amyloid precursor protein Humans ddc:610 Fragmentation (cell biology) Psychiatry Short sleep Amyloid beta-Peptides biology business.industry Health Policy Plasma levels Sleep in non-human animals Psychiatry and Mental health Sleep deprivation 030104 developmental biology Endocrinology biology.protein Sleep Deprivation Female Neurology (clinical) Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer'sdementia : the journal of the Alzheimer's AssociationREFERENCES. 16(5) |
| ISSN: | 1552-5279 |
| Popis: | Introduction In mice there might be an association between sleep deprivation and amyloid β plasma levels. Hence, we examined whether amyloid plasma levels are associated with sleep duration or fragmentation in 17 psychiatrists on-call. Methods Amyloid β (Aβ)42, Aβ40, and soluble amyloid precursor protein β (sAPP-β) plasma concentrations were measured at the beginning and end of 90 on-call nights, and analyzed using generalized linear models. Results In on-call nights, a 10.7% reduction of Aβ42 was revealed overnight. Every single short sleep interruption diminished this reduction by 5.4%, as well as every pg/mL of sAPP-β by 1.2%, each copy of APOE e4 by 10.6%, and each year of professional experience by 3.0%. Discussion The extent of sleep fragmentation diminishes the physiological overnight reduction of Aβ42 but not Aβ40 plasma levels in the same direction as the enzyme for Aβ42 production, the genetic risk factor for Alzheimer's disease (AD), and on-call experience. Might on-call duty and sleep fragmentation in general alter the risk for AD? |
| Databáze: | OpenAIRE |
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