Cranberries after pelvic floor surgery for urinary tract infection prophylaxis: A randomized controlled trial
| Autor: | Jan W de Leeuw, Willem J Liefers, Ellen S Mooren |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Urology Urinary system 030232 urology & nephrology Capsules urologic and male genital diseases Placebo law.invention 03 medical and health sciences 0302 clinical medicine Gynecologic Surgical Procedures Postoperative Complications Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans Aged 030219 obstetrics & reproductive medicine Intention-to-treat analysis Pelvic floor business.industry Plant Extracts Incidence (epidemiology) Incidence Perioperative Pelvic Floor Middle Aged Anti-Bacterial Agents Clinical trial medicine.anatomical_structure Vaccinium macrocarpon Urinary Tract Infections Female Neurology (clinical) business Phytotherapy |
| Zdroj: | Neurourology and urodynamicsREFERENCES. 39(5) |
| ISSN: | 1520-6777 |
| Popis: | Aims Urinary tract infection (UTI) is a common complication after pelvic floor surgery. Antibiotics as prophylaxis may reduce the prevalence of UTI's by 50%, but bacterial resistance may be a large disadvantage, necessitating the search for other possible prophylactic options. Recent research found a 50% reduction in the rate of UTI's with the use of cranberry capsules after elective gynecologic surgery, suggesting that cranberry capsules may serve as a good prophylaxis. The aim of this study was to assess whether perioperative cranberry prophylaxis reduces the risk of clinical overt UTI after elective pelvic floor surgery with indwelling catheter. Methods We conducted a single-center randomized, double-blind, placebo-controlled trial. Women were given cranberry capsules twice daily or identical placebo for 6 weeks, starting the day before surgery. The main endpoint of the trial was the incidence of UTI within 6 weeks after surgery, defined as clinical diagnosis and treatment of UTI by the medical doctor. Analyses were performed with the intention to treat. Results Two hundred ten participants were included, 105 in each arm. There was no significant difference in the prevalence of UTI between the cranberry arm (n = 13, 12.4%) and the placebo arm (n = 21, 20.0%; P = .13), but the prevalence in both arms was lower than anticipated. Conclusions This trial shows no beneficial effect of adequately dosed cranberry prophylaxis in women undergoing pelvic floor surgery, although such effect cannot be ruled out in settings with a higher prevalence of UTI's. |
| Databáze: | OpenAIRE |
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