Predictors of mortality in children admitted with SARS‐CoV‐2 infection to a tertiary care hospital in North India
| Autor: | Ankita Sharma, Suvasini Sharma, Virendra Kumar, Ravitanaya Sodani, Harish K Pemde, Sandip Ray, Abhijeet Saha, Anuja Sapre, Preeti Singh |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Myocarditis Disease Tertiary Care Centers Internal medicine Humans Medicine Hospital Mortality Risk factor Child Retrospective Studies SARS-CoV-2 business.industry Incidence (epidemiology) Acute kidney injury COVID-19 Odds ratio medicine.disease Hospitalization Child Preschool Pediatrics Perinatology and Child Health Female Underweight medicine.symptom business Encephalitis |
| Zdroj: | Journal of Paediatrics and Child Health. 58:432-439 |
| ISSN: | 1440-1754 1034-4810 |
| Popis: | Aim To compare the demographic, clinical, laboratory and radiological parameters of patients with different clinical outcomes (death or discharge) and analyse them to find out the potential predictors for mortality in children hospitalised with SARS-CoV-2 infection. Methods Retrospective chart review of all patients less than 18 years of age with laboratory-confirmed SARS-CoV-2 infection and requiring hospital admission between 16 April 2020 and 31 October 2020. Results Of 255 children with SARS-CoV-2 infection, 100 patients (median age 62.5 months, 59% males, 70% with moderate to severe disease) were hospitalised, of whom 27 died (median age 72 months, 59% males and 30% severely underweight). The subgroup with comorbidities (n = 14) was older (median age 126 months) and had longer duration of stay (median 10 days). Fever and respiratory symptoms were comparable while gastrointestinal symptoms were more common among non-survivors. Hypoxia at admission (odds ratio (OR) 5.48, P = 0.001), multiorgan dysfunction (OR 75.42, P = 0.001), presence of acute kidney injury (OR 11.66, P = 0.001), thrombocytopenia (OR 4.40, P = 0.003) and raised serum C-reactive protein (CRP) (OR 4.69, P = 0.02) were independently associated with mortality. The median time from hospitalisation to death was 3 days. The deceased group had significantly higher median levels of inflammatory parameters and a higher incidence of complications (myocarditis, encephalitis, acute respiratory distress syndrome and shock). Conclusions Hypoxia at admission, involvement of three or more organ systems, presence of acute kidney injury, thrombocytopenia and raised serum C-reactive protein were found to be independently associated with increased odds of in-hospital mortality in children admitted with SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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