LIN28A gene polymorphisms modify neuroblastoma susceptibility: A four‐centre case‐control study
Autor: | Jiwen Cheng, Zhenjian Zhuo, Jing He, Lili Ge, Jiao Zhang, Li Yuan, Jinhong Zhu, Xianwei Zhang, Rui-Xi Hua, Chongfen Chen, Huimin Xia, Jing Liu, Haixia Zhou |
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Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine China medicine.medical_specialty Genotype LIN28A Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology polymorphism neuroblastoma 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Neuroblastoma Biomarkers Tumor Humans Medicine Genetic Predisposition to Disease risk case‐control study business.industry Risk effect Haplotype Case-control study Infant RNA-Binding Proteins Original Articles Cell Biology Odds ratio Prognosis medicine.disease Confidence interval 030104 developmental biology Haplotypes Case-Control Studies 030220 oncology & carcinogenesis Molecular Medicine Female Original Article business Follow-Up Studies |
Zdroj: | Journal of Cellular and Molecular Medicine |
ISSN: | 1582-4934 1582-1838 |
DOI: | 10.1111/jcmm.14827 |
Popis: | Neuroblastoma ranks the most common seen solid tumour in childhood. Overexpression of LIN28A gene has been linked to the development of multiple human malignancies, but the relationship between LIN28A single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility is still under debate. Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China. The correlation strengths were determined by using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Among these SNPs, rs34787247 G>A exhibited a significant association with increased susceptibility in neuroblastoma (GA vs GG: adjusted OR = 1.30, 95% CI = 1.03‐1.64; AA vs GG: adjusted OR = 2.51, 95% CI = 1.36‐4.64, AA/GA vs GG: adjusted OR = 1.42, 95% CI = 1.12‐1.80, AA vs GG/GA: adjusted OR = 2.39, 95% CI = 1.29‐4.42). Furthermore, the combined analysis of risk genotypes revealed that subjects carrying three risk genotypes (adjusted OR = 1.64, 95% CI = 1.02‐2.63) are more inclined to develop neuroblastoma than those without risk genotype, and so do carriers of 1‐4 risk genotypes (adjusted OR = 1.26, 95% CI = 1.01‐1.56). Stratification analysis further revealed risk effect of rs3811464 G>A, rs34787247 G>A and 1‐4 risk genotypes in some subgroups. Haplotype analysis of these four SNPs yields two haplotypes significantly correlated with increased neuroblastoma susceptibility. Overall, our finding indicated that LIN28A SNPs, especially rs34787247 G>A, may increase neuroblastoma risk. |
Databáze: | OpenAIRE |
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