Novozym-435-catalyzed efficient preparation of (1S)-ethenyl and ethynyl 2,3-allenols and (1R)-ethenyl and ethynyl 2,3-allenyl acetates with high enantiomeric excess

Autor: Shengming Ma, Zuyi Li, Daiwang Xu
Rok vydání: 2003
Předmět:
Zdroj: Tetrahedron: Asymmetry. 14:3657-3666
ISSN: 0957-4166
Popis: Novozym-435 (a form of Candida antarctica lipase B ) was found to be an effective biocatalyst for the kinetic resolution of a variety of racemic 1-ethenyl or ethynyl-substituted 2,3-allenols. The optically active 1-ethynyl-substituted 2,3-allenols can be subjected to Sonogashira coupling reactions and alkylations of terminal CC triple bonds leading to the formation of 2,3-allenols, which cannot be directly prepared by Novozym 435-catalyzed kinetic resolution probably due to the steric hindrance.
Databáze: OpenAIRE