Novozym-435-catalyzed efficient preparation of (1S)-ethenyl and ethynyl 2,3-allenols and (1R)-ethenyl and ethynyl 2,3-allenyl acetates with high enantiomeric excess

Autor:	Shengming Ma, Zuyi Li, Daiwang Xu
Rok vydání:	2003
Předmět:	Steric effects Novozym 435 biology Chemistry Organic Chemistry Sonogashira coupling General Medicine biology.organism_classification Triple bond Catalysis Kinetic resolution Inorganic Chemistry Biocatalysis Organic chemistry Candida antarctica Physical and Theoretical Chemistry Enantiomeric excess
Zdroj:	Tetrahedron: Asymmetry. 14:3657-3666
ISSN:	0957-4166
Popis:	Novozym-435 (a form of Candida antarctica lipase B ) was found to be an effective biocatalyst for the kinetic resolution of a variety of racemic 1-ethenyl or ethynyl-substituted 2,3-allenols. The optically active 1-ethynyl-substituted 2,3-allenols can be subjected to Sonogashira coupling reactions and alkylations of terminal CC triple bonds leading to the formation of 2,3-allenols, which cannot be directly prepared by Novozym 435-catalyzed kinetic resolution probably due to the steric hindrance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d2cd581296be83937b508167dd877c https://doi.org/10.1016/j.tetasy.2003.09.048 Zobrazit plný text záznamu Full Text from ScienceDirect