Bactericidal Kinetics of Marine-Derived Napyradiomycins against Contemporary Methicillin-Resistant Staphylococcus aureus
| Autor: | Varahenage R. Perera, Lauge Farnaes, William Fenical, Nina M. Haste, Mary E. Hensler, Victor Nizet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.drug_class Antibiotics Pharmaceutical Science medicine.disease_cause 01 natural sciences Streptomyces Article Microbiology 03 medical and health sciences antibiotic Cell Line Tumor Drug Discovery medicine Humans Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 0303 health sciences biology methicillin-resistant Staphylococcus aureus (MRSA) 010405 organic chemistry 030306 microbiology napyradiomycin antibacterial time-kill biology.organism_classification Methicillin-resistant Staphylococcus aureus 0104 chemical sciences 3. Good health Anti-Bacterial Agents lcsh:Biology (General) Staphylococcus aureus Naphthoquinones |
| Zdroj: | Marine Drugs Marine Drugs, Vol 9, Iss 4, Pp 680-689 (2011) Marine Drugs; Volume 9; Issue 4; Pages: 680-689 |
| ISSN: | 1660-3397 |
| Popis: | There is an urgent need for new antibiotics to treat hospital- and community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections. Previous work has indicated that both terrestrial and marine-derived members of the napyradiomycin class possess potential anti-staphylococcal activities. These compounds are unique meroterpenoids with unusual levels of halogenation. In this paper we report the evaluation of two previously described napyradiomycin derivatives, A80915A (1) and A80915B (2) produced by the marine-derived actinomycete, Streptomyces sp. strain CNQ-525, for their specific activities against contemporary and clinically relevant MRSA. Reported are studies of the in vitro kinetics of these chemical scaffolds in time-kill MRSA assays. Both napyradiomycin derivatives demonstrate potent and rapid bactericidal activity against contemporary MRSA strains. These data may help guide future development and design of analogs of the napyradiomycins that could potentially serve as useful anti-MRSA therapeutics. |
| Databáze: | OpenAIRE |
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