Immune function in patients with acute pancreatitis

Autor: Hiroshi Tomita, Yoshimura Tomita, Soichiro Uehara, Hiroshi Handa, Katsuhiro Gothoh
Rok vydání: 2003
Předmět:
Zdroj: Journal of Gastroenterology and Hepatology. 18:363-370
ISSN: 1440-1746
0815-9319
Popis: Background: The aim of this study was to clarify the relationship between the balance of T-helper (Th)1 and Th2 cytokines, and the numbers of CD4+ T and CD8+ T-cells, and was investigated, together with the plasma concentration of the antigen, an apoptosis marker, in patients with mild and acute pancreatitis (AP). Methods: Plasma concentrations of soluble (s) CD4, sCD8, sIL-2-R, IL-12, IFN-γ and sFas antigen were measured by ELISA, and CD4+ T, and CD8+ T lymphocyte counts were measured by flow cytometry. Results: Both CD4+ T and CD8+ T-cells were reduced in number; in the severe cases the reduction in the former was more pronounced. A significant positive correlation was noted among the concentrations of sCD4, sIL-2-R and IL-12, and a significant positive correlation was also found between sCD4 and sFas. During the early stage of AP, the concentrations of sCD4, sCD8, sIL-2-R, IL-12 and IFN-γ increased more in the severe cases compared with those who had milder symptoms; however, these increases were moderated during the clinical course. Conclusion: We considered that these Th1 type CD4+ T cells probably induce the activation of macrophages and further pro-inflammatory reactions during the early stage of AP, as well as exerting direct cytotoxicity effects through Fas/Fas ligand expression. © 2003 Blackwell Publishing Asia Pty Ltd
Databáze: OpenAIRE
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