Nicotinamide and its effects on endothelial dysfunction and secretion of antiangiogenic factors by primary human placental cells and tissues
| Autor: | Natalie K Binder, Fiona C Brownfoot, Laura Tuohey, Emerson Keenan, Sally Beard, Natalie J. Hannan, Stephen Tong, Alesia Harper, Roxanne Hastie |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Niacinamide medicine.medical_specialty Placenta Primary Cell Culture Angiogenesis Inhibitors Preeclampsia Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy Internal medicine medicine Human Umbilical Vein Endothelial Cells Humans Secretion Endothelial dysfunction reproductive and urinary physiology Cells Cultured 030219 obstetrics & reproductive medicine Proteinuria Nicotinamide business.industry Obstetrics and Gynecology medicine.disease 030104 developmental biology medicine.anatomical_structure Endocrinology Reproductive Medicine chemistry embryonic structures Blood Vessels Female Endothelium Vascular medicine.symptom business Tyrosine kinase Developmental Biology |
| Zdroj: | Placenta. 109 |
| ISSN: | 1532-3102 |
| Popis: | Preeclampsia is a serious pregnancy complication associated with elevated antiangiogenic markers and endothelial dysfunction. Recently nicotinamide (vitamin B3) was shown to reduce high blood pressure and proteinuria in mice models of the disease. Using primary human pregnancy tissue we show nicotinamide did not change antiangiogenic factor secretion including soluble fms-like tyrosine kinase 1 or soluble endoglin from primary cytotrophoblasts and placental explants. Furthermore, it did not reverse markers of endothelial dysfunction. Therefore, we did not demonstrate an effect of nicotinamide on reducing markers of preeclampsia from primary human placental tissues and vascular cells. |
| Databáze: | OpenAIRE |
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