Remarkable changes in the plasma levels of pituitary protein '7B2' during childhood
| Autor: | Shoichi Natori, Ken-Ichi Kato, Hajime Nawata, Naoki Takayanagi, Haruo Iguchi, Hitoshi Kohno, Yuichi Niida |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Adolescent Nerve Tissue Proteins Gonadotropin-Releasing Hormone chemistry.chemical_compound Neuroendocrine Secretory Protein 7B2 Dehydroepiandrosterone sulfate Internal medicine medicine Humans Child Infusions Intravenous Aged Aged 80 and over business.industry Infant Newborn Infant Plasma levels Middle Aged Pituitary Hormones Endocrinology chemistry Child Preschool Pituitary Gland Pediatrics Perinatology and Child Health Chromatography Gel Female business Luteinizing hormone Adult level Hormone |
| Zdroj: | Pediatric research. 24(2) |
| ISSN: | 0031-3998 |
| Popis: | We measured plasma immunoreactive (IR)-7B2 concentrations in 96 children (57 males and 39 females) from the newborn period to 20 yr of age. Plasma IR-7B2 concentrations in infants less than 2 yr of age (range 175-580 pg/ml, n = 19) were much higher than those in adults (range 20-138 pg/ml). Plasma levels of IR-7B2 decreased with age during childhood to reach the adult level at 15-20 yr. Significant negative correlations were found between plasma levels of IR-7B2 and dehydroepiandrosterone sulfate (r = -0.4154, p less than 0.05, n = 27), luteinizing hormone (r = -0.4948, p less than 0.05, n = 20) and follicle-stimulating hormone (r = -0.4682, p less than 0.05, n = 20). The possibility of a relationship between the reduction of plasma IR-7B2 levels and pubertal development warrants attention. |
| Databáze: | OpenAIRE |
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