VADER: a variable dose-rate external 137Cs irradiator for internal emitter and low dose rate studies
Autor: | Shanaz A. Ghandhi, Sally A. Amundson, Peter F. Caracappa, Evagelia C. Laiakis, David J. Brenner, Rompin Shih, Albert J. Fornace, Qi Wang, David E. Cuniberti, Shad R. Morton, Lubomir B. Smilenov, Thomas L. Morgan, Carlos Bueno-Beti, Helen Turner, Guy Garty, Gary W. Johnson, Yanping Xu, Monica Pujol-Canadell, Robert C. Morton, Simon Joseph |
---|---|
Rok vydání: | 2020 |
Předmět: |
Multidisciplinary
Materials science Nuclear engineering medicine.medical_treatment lcsh:R Brachytherapy FOS: Physical sciences food and beverages lcsh:Medicine External irradiation Radiation Physics - Medical Physics 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Computer control 030220 oncology & carcinogenesis medicine lcsh:Q Medical Physics (physics.med-ph) Low dose rate Irradiation lcsh:Science Dose rate Common emitter |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
ISSN: | 2045-2322 |
Popis: | In the long term, 137Cs is probably the most biologically important agent released in many accidental (or malicious) radiation disasters. It can enter the food chain, and be consumed, or, if present in the environment (e.g. from fallout), can provide external irradiation over prolonged times. In either case, due to the high penetration of the energetic γ rays emitted by 137Cs, the individual will be exposed to a low dose rate, uniform, whole body, irradiation. The VADER (VAriable Dose-rate External 137Cs irradiatoR) allows modeling these exposures, bypassing many of the problems inherent in internal emitter studies. Making use of discarded 137Cs brachytherapy seeds, the VADER can provide varying low dose rate irradiations at dose rates of 0.1 to 1.2 Gy/day. The VADER includes a mouse “hotel”, designed to allow long term simultaneous residency of up to 15 mice. Two source platters containing ~ 250 mCi each of 137Cs brachytherapy seeds are mounted above and below the “hotel” and can be moved under computer control to provide constant low dose rate or a varying dose rate mimicking 137Cs biokinetics in mouse or man. We present the VADER design and characterization of its performance over 18 months of use. |
Databáze: | OpenAIRE |
Externí odkaz: |