Structural glycobiology in the age of electron cryo-microscopy
| Autor: | Jon Agirre, Mihaela Atanasova, Haroldas Bagdonas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular 0303 health sciences Engineering Molecular Structure business.industry Glycobiology Resolution (electron density) Cryoelectron Microscopy Nanotechnology 03 medical and health sciences 0302 clinical medicine Structural Biology business Molecular Biology Glycomics 030217 neurology & neurosurgery Software 030304 developmental biology Glycoproteins |
| ISSN: | 0959-440X |
| Popis: | The methodology underpinning the construction, refinement, validation and analysis of atomic models of glycoproteins and protein-carbohydrate complexes has received a long-overdue boost in the last five years. This is a very timely development, as the resolution revolution in electron cryo-microscopy is now routinely delivering structures of key glycomedical importance, with a three-dimensional precision where X-ray crystallographic methods have traditionally floundered. This review will focus on the new software developments that have been introduced in the past two years, and their impact on the field of structural glycobiology in terms of published structures. |
| Databáze: | OpenAIRE |
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