Intestinal permeability in patients with chronic liver diseases: Its relationship with the aetiology and the entity of liver damage
| Autor: | Carmela Loguercio, Rita Cariello, Pasquale Esposito, Maria Cartenì, Agnese Miranda, Anna Sapone, Piero Portincasa, Concetta Tuccillo, L. Martorelli, Camillo Del Vecchio Blanco, Giuseppe Palasciano, A. Tiso, Veronica Carbonara, Valeria Rita Scialdone, Alessandro Federico |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Liver Cirrhosis Male Pathology medicine.medical_specialty Cirrhosis Gastroenterology Proinflammatory cytokine Diabetes Complications Pathogenesis Liver disease Internal medicine Diabetes mellitus Hypertension Portal medicine Humans Mannitol Nitrites Aged Hepatitis Chronic S-Nitrosothiols Intestinal permeability Hepatology medicine.diagnostic_test Interleukin-6 Tumor Necrosis Factor-alpha business.industry Age Factors Middle Aged medicine.disease Lactulose Alcoholism Intestinal Absorption Case-Control Studies Portal hypertension Female business Liver function tests |
| Zdroj: | Digestive and Liver Disease. 42:200-204 |
| ISSN: | 1590-8658 |
| Popis: | Background Alteration in intestinal permeability may be an important factor in the pathogenesis of both the progression of some chronic liver diseases and the onset of some complications in patients with liver cirrhosis. Aims To investigate the relationships between intestinal permeability, portal hypertension, alcohol use, plasma levels of pro-inflammatory cytokines, and nitric oxide, expressed as s-nitrosothiols, and nitrite levels in patients with various types and degrees of chronic liver diseases. Methods 134 healthy volunteers and 83 patients with chronic liver damage entered the study. Intestinal permeability was assessed with the lactulose/mannitol test. Plasma levels of tumour necrosis factor-alpha, interleukin-6, and nitrite and total s-nitrosothiols were determined. Results Intestinal permeability was altered in patients with advanced liver disease and impaired in 15–35% of patients without cirrhosis. Independent factors for intestinal permeability alteration were age, portal hypertension, alcohol use, and diabetes. Plasma levels of inflammatory cytokines and nitrosothiols were significantly higher in patients with altered intestinal permeability. Conclusions An intestinal permeability evaluation in patients with chronic liver diseases might clarify the significance of intestinal permeability in the pathophysiology of both the progression of liver damage, and the occurrence of complications that accompany liver cirrhosis. |
| Databáze: | OpenAIRE |
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