Synthesis, crystal structure, and characterization of two metal-quinolone compounds
| Autor: | Stane Zalar, Ivan Leban, Iztok Turel, Nataša Bukovec, Gerd Klintschar |
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| Rok vydání: | 1997 |
| Předmět: |
Models
Molecular medicine.drug_class chemistry.chemical_element Protonation Microbial Sensitivity Tests Crystal structure Quinolones Crystallography X-Ray Biochemistry Oxygen Inorganic Chemistry Metal Structure-Activity Relationship Anti-Infective Agents medicine Molecule Bacteria Molecular Structure Chemistry Fungi Hydrogen atom Quinolone Anti-Bacterial Agents Characterization (materials science) Crystallography Metals visual_art visual_art.visual_art_medium |
| Zdroj: | Journal of Inorganic Biochemistry. 66:77-82 |
| ISSN: | 0162-0134 |
| Popis: | Two novel metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic, and X-ray diffraction methods. The crystal structure of both, (erxH2) [FeCl4]Cl and (kinoH2)[CuCl4]. H2O, is presented and discussed (erxH2 = doubly protonated form of enrofloxacin, kinoH2 = doubly protonated form of the second quinolone). In both compounds, the hydrogen atom is bonded between the 4-keto oxygen O(1) and carboxylic oxygen O(11), thus preventing the bonding of the metal to this part of the molecule. Antimicrobial activities of metal-quinolone compounds were tested against different microorganisms. |
| Databáze: | OpenAIRE |
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