Relationship between Apoptosis and Expression of Heat Shock Proteins in Peripheral Blood Lymphocytes of Patients with Myocardial Infarction
| Autor: | E. V. Konstantinova, A. V. Podkolzina, N. A. Konstantinova, N. F. Khomyakova, Alexander M. Sapozhnikov |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Programmed cell death medicine.medical_specialty Myocardial Infarction Apoptosis Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Internal medicine Heat shock protein Humans Medicine Myocytes Cardiac In patient Lymphocytes Myocardial infarction Heat-Shock Proteins Aged Aged 80 and over business.industry Ischemic injury General Medicine Middle Aged medicine.disease Peripheral blood Endocrinology Case-Control Studies Immunology Female business Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 150:682-684 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-011-1222-2 |
| Popis: | We studied activity and dynamics of apoptosis of peripheral blood lymphocytes in patients with myocardial infarction and analyzed the relationship of these processes with expression of heat shock proteins with a molecular weight of 70 kDa playing an essential role in preventing cell death. Thus, we first demonstrated activation of apoptosis in peripheral blood cells of patients with myocardial infarction compared to the control (healthy individuals) and revealed the expected negative correlation between the expression of heat shock proteins with a molecular weight of 70 kDa by lymphocytes and intensity of their death. The observed dynamics of mononuclear cell apoptosis in the peripheral blood of patients with myocardial infarction can reflect activity of programmed cardiomyocyte death in the focus of ischemic injury. |
| Databáze: | OpenAIRE |
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