Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury
| Autor: | Likun Gong, Jin-hui Dou, Wen-jie Wang, Shou-yan Wu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Liver injury Traditional medicine business.industry Liver Diseases Immune regulation General Medicine Review Article Additional comments medicine.disease Protective Agents 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Liver 030220 oncology & carcinogenesis medicine Animals Glycyrrhetinic Acid Humans Pharmacology (medical) Meaning (existential) business |
| Zdroj: | Acta Pharmacol Sin |
| ISSN: | 1745-7254 |
| Popis: | The first description of the medical use of licorice appeared in "Shennong Bencao Jing", one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as "Guo Lao", meaning "a national treasure" in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18β-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18β-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18β-glycyrrhetinic acid and avoid potential risks. |
| Databáze: | OpenAIRE |
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