Acitretin Biotransformation into Etretinate: Role of Ethanol on in vitro Hepatic Metabolism
| Autor: | J.-M. Geiger, R. Rahmani, J.-P. Laugier, H. Bun, G. de Sousa, Christian Surber |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Etretinate Dermatology Biology Acitretin chemistry.chemical_compound Dogs Biotransformation Internal medicine medicine Animals Humans Rats Wistar Cells Cultured Ethanol Esterification Metabolism Rats Macaca fascicularis medicine.anatomical_structure Endocrinology Liver chemistry Cell culture Hepatocyte Drug metabolism medicine.drug |
| Zdroj: | Dermatology. 188:122-125 |
| ISSN: | 1421-9832 1018-8665 |
| DOI: | 10.1159/000247115 |
| Popis: | The aim of this study was to investigate the possible esterification of acitretin into etretinate by using hepatocytes in primary culture from the rat, monkey, dog and man. With rat and human hepatocytes, etretinate was detectable only when ethanol was co-administered with acitretin. With monkey and dog cells, traces of etretinate were found without ethanol addition, but the esterification of acitretin was highly enhanced by ethanol. The metabolic profile was not changed when cells were pre-incubated with ethanol. Therefore acitretin seems to act rather as a substrate than an enzymatic inducer. |
| Databáze: | OpenAIRE |
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