Low Baseline High-Sensitive C-Reactive Protein is Associated with Coronary Atherosclerosis Regression: Insights from the MILLION Study

Autor: Masa-aki Kawashiri, Kenji Sakata, Hayato Tada, Masakazu Yamagishi, Tadatsugu Gamou, Hidekazu Ino, Kenshi Hayashi
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Atorvastatin
Coronary Artery Disease
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Intravascular ultrasound
Internal Medicine
Medicine
Humans
Amlodipine
Prospective Studies
Coronary atherosclerosis
Antihypertensive Agents
Aged
biology
medicine.diagnostic_test
business.industry
Biochemistry (medical)
C-reactive protein
Percutaneous coronary intervention
Middle Aged
Prognosis
Blood pressure
medicine.anatomical_structure
C-Reactive Protein
High-Sensitivity C-Reactive Protein
biology.protein
Cardiology
Female
Original Article
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Biomarkers
medicine.drug
Artery
Follow-Up Studies
Zdroj: Journal of Atherosclerosis and Thrombosis
ISSN: 1880-3873
Popis: Aim: The prospective, randomized, multicenter Myocardial Ischemia Treated with Percutaneous Coronary Intervention and Plaque Regression by Lipid Lowering & Blood Pressure Controlling assessed by Intravascular Ultrasonography (MILLION) study demonstrated that combined treatment with atorvastatin and amlodipine enhanced coronary artery plaque regression. Although the baseline high-sensitive C-reactive protein (hs-CRP) reportedly plays an important role in atherogenesis, few data exist regarding the relationship between hs-CRP and plaque regression in patients receiving a combined atorvastatin and amlodipine therapy. Methods: A total of 68 patients (male, 55; mean age, 64.2 years) with baseline and follow-up 3-dimensional intravascular ultrasound examinations in the MILLION study were stratified by baseline hs-CRP level quartiles. The serial measurements of lipid, blood pressure, and percentage changes in the plaque volume were compared between the groups, and the factors associated with the percentage change in the plaque volume were assessed. Results: There were no significant between-group differences in the extent of change in low-density lipoprotein cholesterol (LDL-C) or systolic and diastolic blood pressure after 18–24 months of treatment. The percentage change in the plaque volume showed a linear association with the baseline hs-CRP (p for trend < 0.05); however, there was no correlation with changes in LDL-C or systolic and diastolic blood pressure. In the multiple regression analysis, the baseline hs-CRP level was independently associated with the percentage change in the plaque volume (β = 0.29, p = 0.022). Conclusions: Coronary plaque regression was associated with the baseline hs-CRP level in patients treated with a combined lipid- and blood pressure-lowering therapy.
Databáze: OpenAIRE
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