The implications of war captivity and long-term psychopathology trajectories for telomere length
| Autor: | Orit Uziel, Zahava Solomon, Avi Ohry, Yafit Levin, Noga Tsur, Meir Lahav |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Captivity Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Endocrinology Prisoners of War Leukocytes medicine Humans Longitudinal Studies Prospective Studies Psychiatry Telomere Shortening Biological Psychiatry Depression (differential diagnoses) Aged Depression Endocrine and Autonomic Systems Chronic depression Delayed onset Middle Aged humanities 030227 psychiatry Telomere Psychiatry and Mental health Cellular Aging Case-Control Studies Female Psychology 030217 neurology & neurosurgery Prisoners of war Psychopathology |
| Zdroj: | Psychoneuroendocrinology. 81:122-128 |
| ISSN: | 0306-4530 |
| Popis: | Background Previous findings have demonstrated the link between trauma, its psychopathological aftermath and cellular aging, as reflected in telomere length. However, as long-term examinations of psychopathology following trauma are scarce, very little is known regarding the repercussions of depression and PTSD trajectories of psychopathology for telomeres. The current study examined the implications of war captivity and depression/PTSD trajectories on telomere length. Methods Ninety-nine former prisoners of war (ex-POWs) from the 1973 Yom Kippur War were evaluated for depression and PTSD at 18, 30, 35 and 42 years after the war. Data on leukocyte telomere length of ex-POWs and 79 controls was collected 42 years after the war. Results Ex-POWs had shorter telomeres compared to controls (Cohen's d = .5 indicating intermediate effect). Ex-POWs with chronic depression had shorter telomeres compared to those with delayed onset of depression (Cohen's d = 4.89), and resilient ex-POWs (Cohen's d = 3.87), indicating high effect sizes. PTSD trajectories were not implicated in telomere length (Partial eta 2 = .16 and p = .11). Conclusion The findings suggest that the detrimental ramifications of war captivity are extensive, involving premature cellular senesces. These findings further point to the wear-and-tear effect of long-term depression, but not PTSD, on telomere length. Explanations for the findings are discussed. |
| Databáze: | OpenAIRE |
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