Developmental Vitamin D Deficiency in Pregnant Rats Does Not Induce Preeclampsia
| Autor: | Asad Ali, Suzanne Alexander, Darryl W. Eyles, Pauline Ko, John J. McGrath, Andrew J. O. Whitehouse, James S. M. Cuffe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Placenta
Pre-Eclampsia Pregnancy oxidative stress TX341-641 Vitamin D renin–angiotensin system reproductive and urinary physiology Nutrition and Dietetics female genital diseases and pregnancy complications Prenatal Exposure Delayed Effects embryonic structures Gestation Animal Nutritional Physiological Phenomena Female medicine.medical_specialty Offspring maternal vitamin D deficiency vitamin D deficiency Article preeclampsia placental insufficiencies Preeclampsia Internal medicine medicine Vitamin D and neurology Placental insufficiencies Animals Risk factor Autistic Disorder business.industry Nutrition. Foods and food supply Maternal vitamin D deficiency Maternal Nutritional Physiological Phenomena medicine.disease Vitamin D Deficiency Renin–angioten-sin system Rats Pregnancy Complications Disease Models Animal Endocrinology Animals Newborn Oxidative stress Schizophrenia Autism business Food Science Pregnancy disorder |
| Zdroj: | Nutrients, Vol 13, Iss 4254, p 4254 (2021) Nutrients Ali, A, Alexander, S, Ko, P, Cuffe, J S M, Whitehouse, A J O, McGrath, J J & Eyles, D 2021, ' Developmental Vitamin D Deficiency in Pregnant Rats Does Not Induce Preeclampsia ', Nutrients, vol. 13, no. 12, 4254 . https://doi.org/10.3390/nu13124254 Nutrients; Volume 13; Issue 12; Pages: 4254 Ali, A, Alexander, S, Ko, P, Cuffe, J S M, Whitehouse, A J O, McGrath, J J & Eyles, D 2021, ' Developmental Vitamin D Deficiency in Pregnant Rats Does Not Induce Preeclampsia ', Nutrients, vol. 13, no. 12 . https://doi.org/10.3390/nu13124254 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13124254 |
| Popis: | Preeclampsia is a pregnancy disorder characterized by hypertension. Epidemiological studies have associated preeclampsia with an increased risk of neurodevelopmental disorders in offspring, such as autism and schizophrenia. Preeclampsia has also been linked with maternal vitamin D deficiency, another candidate risk factor also associated with autism. Our laboratory has established a gestational vitamin-D-deficient rat model that shows consistent and robust behavioural phenotypes associated with autism- and schizophrenia-related animal models. Therefore, we explored here whether this model also produces preeclampsia as a possible mediator of behavioural phenotypes in offspring. We showed that gestational vitamin D deficiency was not associated with maternal blood pressure or proteinuria during late gestation. Maternal and placental angiogenic and vasculogenic factors were also not affected by a vitamin-D-deficient diet. We further showed that exposure to low vitamin D levels did not expose the placenta to oxidative stress. Overall, gestational vitamin D deficiency in our rat model was not associated with preeclampsia-related features, suggesting that well-described behavioural phenotypes in offspring born to vitamin-D-deficient rat dams are unlikely to be mediated via a preeclampsia-related mechanism. |
| Databáze: | OpenAIRE |
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