Pyrazolo[1,5-a]pyrimidines. Identification of the Privileged Structure and Combinatorial Synthesis of 3-(Hetero)arylpyrazolo[1,5-a]pyrimidine-6-carboxamides

Autor:	Dana A. Razzano, Matthew R. Johnson, Dmytro O. Tymoshenko, Brian T. Gregg
Rok vydání:	2007
Předmět:	Molecular Structure Pyrimidine Leaving group Stereoisomerism General Chemistry General Medicine Combinatorial synthesis Amides Combinatorial chemistry chemistry.chemical_compound Pyrimidines chemistry Reagent Combinatorial Chemistry Techniques Organic chemistry Molecule
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200738159
Popis:	The pyrazolo[1,5-a]pyrimidine class of compounds has been identified as a privileged structure for library synthesis on the basis of several key characteristics of the core molecule. A chemical set in excess of 400 compounds was synthesized to give 3,6,7-substituted pyrazolo[1,5-a]pyrimidinecarboxamides 9. To facilitate the rapid preparation of this library, a preparative strategy included the synthesis of activated p-nitrophenyl esters, followed by subsequent scavenging of the p-nitrophenol leaving group. Excess reagents were also removed using scavenging reagents that were found to be compatible with the synthetic methodology and that afforded target compounds in acceptable purity and yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b5bb64b4fca0ff775bc910fc3e7513 https://doi.org/10.1002/chin.200738159 Zobrazit plný text záznamu Plný text