Epstein–Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship
Autor: | Andrew Wotherspoon, Roberto N. Miranda, Neill Patani, Luis Malpica, Aliyah R. Sohani, Beth A. Sieling, Francisco Vega, Swaminathan P. Iyer, Chris M. Bacon, J.M. O'Donoghue, Fiona MacNeill, Edward M. Pina, Daniel C. Mills, Winston B. Magno, Christine Khoo, Jerzy Morkowski, Laura Johnson, Mark Silberman, Mark G. Evans, Jie Xu, Andrew L. Feldman, Jennifer R. Chapman, L. Jeffrey Medeiros, Mario L. Marques-Piubelli, Mark W. Clemens, Keyur P. Patel, Roberto Ruiz-Cordero, Suzanne D. Turner, Christopher M. Bates, Despina Televantou, Kelly K. Hunt, Valentina Fabiola Ilenia Sangiorgio, Stephen Lade |
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Přispěvatelé: | Medeiros, L Jeffrey [0000-0001-6577-8006], Marques-Piubelli, Mario L [0000-0002-6324-2096], Ruiz-Cordero, Roberto [0000-0002-9747-6069], Vega, Francisco [0000-0001-5956-452X], Feldman, Andrew L [0000-0001-5009-4808], Hunt, Kelly K [0000-0001-9156-8723], Sohani, Aliyah R [0000-0002-6307-4854], Turner, Suzanne D [0000-0002-8439-4507], Patel, Keyur P [0000-0001-5081-2427], Xu, Jie [0000-0001-9163-3898], Miranda, Roberto N [0000-0002-8467-5464], Apollo - University of Cambridge Repository |
Rok vydání: | 2021 |
Předmět: |
Adult
Epstein-Barr Virus Infections Pathology medicine.medical_specialty Surface Properties Breast Implants Prosthesis Design Virus Pathology and Forensic Medicine law.invention Diagnosis Differential Immunophenotyping Predictive Value of Tests Risk Factors law hemic and lymphatic diseases Biomarkers Tumor medicine Humans Neoplasm B-cell lymphoma Breast Implantation Anaplastic large-cell lymphoma Aged Neoplasm Staging business.industry Middle Aged medicine.disease Lymphoma Breast implant Lymphoma Large-Cell Anaplastic Female Lymphoma Large B-Cell Diffuse business Calcification |
Zdroj: | Modern Pathology. 34:2154-2167 |
ISSN: | 0893-3952 |
Popis: | Breast implant anaplastic large cell lymphoma (ALCL) is a T-cell neoplasm arising around textured breast implants that was recognized recently as a distinct entity by the World Health Organization. Rarely, other types of lymphoma have been reported in patients with breast implants, raising the possibility of a pathogenetic relationship between breast implants and other types of lymphoma. We report eight cases of Epstein-Barr virus (EBV)-positive large B-cell lymphoma associated with breast implants. One of these cases was invasive, and the other seven neoplasms were noninvasive and showed morphologic overlap with breast implant ALCL. All eight cases expressed B-cell markers, had a non-germinal center B-cell immunophenotype, and were EBV+ with a latency type III pattern of infection. We compared the noninvasive EBV+ large B-cell lymphoma cases with a cohort of breast implant ALCL cases matched for clinical and pathologic stage. The EBV+ large B-cell lymphoma cases more frequently showed a thicker capsule, and more often were associated with calcification and prominent lymphoid aggregates outside of the capsule. The EBV+ B-cell lymphoma cells were more often arranged within necrotic fibrinoid material in a layered pattern. We believe that this case series highlights many morphologic similarities between EBV+ large B-cell lymphoma and breast implant ALCL. The data presented suggest a pathogenetic role for breast implants (as well as EBV) in the pathogenesis of EBV+ large B-cell lymphoma. We also provide some histologic findings useful for distinguishing EBV+ large B-cell lymphoma from breast implant ALCL in this clinical setting. |
Databáze: | OpenAIRE |
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