Measurement Floors and Dynamic Ranges of OCT and OCT Angiography in Glaucoma
| Autor: | James A. Proudfoot, Rafaella C. Penteado, Christopher Bowd, Kyle Hasenstab, Robert N. Weinreb, Sasan Moghimi, Patricia Isabel C. Manalastas, Huiyuan Hou, Linda M. Zangwill, Elham Ghahari |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Retinal Ganglion Cells
Male medicine.medical_specialty Tissue thickness Clinical Sciences Glaucoma Neurodegenerative Eye Ophthalmology & Optometry 03 medical and health sciences 0302 clinical medicine Oct angiography Nerve Fibers Clinical Research Opthalmology and Optometry Ophthalmology medicine Advanced disease Humans Eye Disease and Disorders of Vision Tomography 030304 developmental biology Decibel Aged 0303 health sciences business.industry Neurosciences Angiography Change point model Retinal Vessels Middle Aged medicine.disease Visual field Cross-Sectional Studies Optical Coherence 030221 ophthalmology & optometry Public Health and Health Services Female Visual Fields business |
| Zdroj: | Ophthalmology, vol 126, iss 7 |
| Popis: | PurposeTo determine if OCT angiography (OCTA)-derived vessel density measurements can extend the available dynamic range for detecting glaucoma compared with spectral-domain (SD) OCT-derived thickness measurements.DesignObservational, cross-sectional study.ParticipantsA total of 509 eyes from 38 healthy participants, 63 glaucoma suspects, and 193 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study.MethodsRelative vessel density and tissue thickness measurement floors of perifoveal vessel density (pfVD), circumpapillary capillary density (cpCD), circumpapillary retinal nerve fiber (cpRNFL) thickness, ganglion cell complex (GCC) thickness, and visual field (VF) mean deviation (MD) were investigated and compared with a previously reported linear change point model (CPM) and locally weighted scatterplot smoothing curves.Main outcome measuresEstimated vessel density and tissue thickness measurement floors and corresponding dynamic ranges.ResultsVisual field MD ranged from -30.1 to 2.8 decibels (dB). No measurement floor was found for pfVD, which continued to decrease constantly until very advanced disease. A true floor (i.e., slope of approximately 0 after observed CPM change point) was detected for cpRNFL thickness only. The post-CPM estimated floors were 49.5±2.6 μm for cpRNFL thickness, 70.7±1.0 μm for GCC thickness, and 31.2±1.1% for cpCD. Perifoveal vessel density reached the post-CPM estimated floor later in the disease (VF MD, -25.8±3.8 dB) than cpCD (VF MD, -19.3±2.4 dB), cpRNFL thickness (VF MD, -17.5±3.3 dB), and GCC thickness (VF MD, -13.9±1.8 dB; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|