| Autor: |
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure S1 shows the gating scheme and markers used to phenotype various T cell subsets in human blood. Supplementary Figure S2 shows the expression of GITR on human and cynomolgus monkey NK cells and T cells. Supplementary Figure S3 shows the expression of GITR on various human tumor infiltrating T cell subsets. Supplementary Figure S4 shows the phenotypic and functional characterization of CD4+ CD25+ TILs from NSCLC tumor tissues. Supplementary Figure S5 shows the phenotypic and functional characterization of iTregs generated in MLR cultures. Supplementary Figure S6 shows the differential effects of MK-4166 when added to MLR cultures on Day 0 vs Day 7. Supplementary Figure S7 shows the potential of MK-4166 to induce ADCC when bound to human iTregs. Supplementary Figure S8 shows the attenuation of nTreg suppression by MK-4166. Supplementary Figure S9 shows the purity of enriched nTregs used in Treg suppression assays. Supplementary Figure S10 shows the effect of MK-4166 on nTreg proliferation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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