Synthesis and biological evaluation of isoxazole, oxazole, and oxadiazole containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors
| Autor: | Nitin J. Deshmukh, H. Sivaramakrishnan, Arno A. Enose, Shaila Srinivasan, Shivaji Kandre, Amol Dixit, Kishorkumar Shivajirao Kadam, Rajiv Sharma, Lalit S. Doshi, M. Mahesh Kumar Reddy, Tandra Guha, Ashok Kumar Gangopadhyay, Ram A. Vishwakarma, Ravindra Dnyandev Jadhav, Amol Gupte, Kumar V.S. Nemmani, Nisha Potdar, Manoja K. Brahma |
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| Rok vydání: | 2012 |
| Předmět: |
Oxadiazole
Chemistry Techniques Synthetic chemistry.chemical_compound Inhibitory Concentration 50 Mice Structure-Activity Relationship In vivo Drug Discovery Structure–activity relationship Organic chemistry Animals Humans Urea Diacylglycerol O-Acyltransferase Isoxazole Solubility Enzyme Inhibitors Oxazole Pharmacology chemistry.chemical_classification Oxadiazoles Organic Chemistry Water General Medicine Isoxazoles In vitro Enzyme chemistry |
| Zdroj: | European journal of medicinal chemistry. 54 |
| ISSN: | 1768-3254 |
| Popis: | Diacylglycerol acyltransferase, DGAT1, is a promising target enzyme for obesity due to its involvement in the committed step of triglyceride biosynthesis. Amino biphenyl carboxylic acids, exemplified by compound 4, are known potent inhibitors of hDGAT1. However the high cLogP and poor solubility of these biphenyl analogs might tend to limit their development. We have synthesized and evaluated compounds containing 3-phenylisoxazole, 5-phenyloxazole, and 3-phenyl-1,2,4-oxadiazole biaryl units for their hDGAT1 inhibition. Our aim in synthesizing such heterocyclic analogs was to improve the cLogP and solubility of these molecules while retaining hDGAT1 potency. Several compounds within the 3-phenylisoxazole series exhibited potent hDGAT1 inhibition when evaluated using an in vitro enzymatic assay. Certain promising compounds were studied for their potential to reduce triglyceride levels using an in vivo fat tolerance test in mice and were also evaluated for any possible improvement to their solubility. Compound 40a (IC(50) = 64 nM) with an in vivo plasma triglyceride reduction of 90 percent, and a solubility of 0.43 mg/ml at pH 7.4 may serve as a new lead for developing newer anti-obesity agents. |
| Databáze: | OpenAIRE |
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