A 3D polyhedral metal–organic framework as drug carrier for controllable release
| Autor: | H. D. Zeng, S. W. Qiu, J. C. Jin, J. Q. Liu, E. H. Zhou, R. Wang, J. W. Xu, J. Wu, H. R. Zhong |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Chemistry media_common.quotation_subject In vitro cytotoxicity 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Drug vehicle lcsh:Chemistry lcsh:QD1-999 Release Material Degradation Drug delivery Porous MOF Metal-organic framework 0210 nano-technology Drug carrier Cytotoxicity Drug delivery Release Porous MOF media_common Nuclear chemistry |
| Zdroj: | Bulletin of the Chemical Society of Ethiopia; Vol 31, No 3 (2017); 457-463 Bulletin of the Chemical Society of Ethiopia, Vol 31, Iss 3, Pp 457-463 (2018) |
| ISSN: | 1726-801X 1011-3924 |
| DOI: | 10.4314/bcse.v31i3.9 |
| Popis: | A new fabrication of {[H 3 O][Cu 6 (tpta) 3 (DMA) 4 (COO)]∙12H 2 O∙7DMA} ( 1 ) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1 . Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery. KEY WORDS : Drug delivery, Release, Porous MOF Bull. Chem. Soc. Ethiop. 2017 , 31(3), 457-463. DOI: http://dx.doi.org/10.4314/bcse.v31i3.9 |
| Databáze: | OpenAIRE |
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