Difference between two hybrid stocks of mice in the incidence of congenital abnormalities following X-ray exposure of stem-cell spermatogonia
| Autor: | Katherine T. Cain, Joe C. Rutledge, L.A. Hughes, Walderico M. Generoso, P.W. Braden |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Ratón Health Toxicology and Mutagenesis Male mice Chromosome Disorders Chromosomal translocation Biology Abnormalities Radiation-Induced Radiation Tolerance Translocation Genetic Andrology Mice Pregnancy Gene duplication Genetics Animals Fetal Death Molecular Biology Chromosome Aberrations Mice Inbred C3H X-Rays X ray exposure Spermatozoa Embryonic stem cell Sperm Spermatogonia Mice Inbred C57BL Female Stem cell |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 163:299-302 |
| ISSN: | 0027-5107 |
| DOI: | 10.1016/0027-5107(86)90028-x |
| Popis: | Unbalanced (duplication/deficiency) sperm from balanced reciprocal translocations induced in spermatogonial stem cells of mice generally lead to embryonic lethality around the time of implantation. In a recent study (Generoso et al., 1985), it was found that the incidence of X-ray-induced embryonic lethality differed markedly between two hybrid stocks of irradiated male mice. A parallel difference in the frequencies of reciprocal translocations was observed cytologically in the meiocytes of irradiated males. In the present report, which is an adjunct to the study by Generoso et al. (1985), it was determined whether or not similar differences between the two stocks exist for congenital defects resulting from genetic damage to stem-cell spermatogonia. The results indicate not only an association between the frequencies of induced reciprocal translocations and congenital abnormalities, but also a parallel greater frequency of induced malformations in the (C3H × 101)F1 stock versus the (SEC × C57BL)F1 stock of males. |
| Databáze: | OpenAIRE |
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