Therapeutic effects and anti-metastasis effects of cationic liposomes against pancreatic cancer metastasis in vitro and in vivo
| Autor: | Muneaki Motomura, Hideaki Ichihara, Yoko Matsumoto |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
MMP2 endocrine system diseases Biophysics MMP9 Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Cell Movement In vivo Cations Cell Line Tumor Pancreatic cancer Ethylamines medicine Animals Humans Neoplasm Invasiveness Cationic liposome Molecular Biology Mice Inbred BALB C Chemistry Matrigel Invasion Assay Cell Biology medicine.disease In vitro Pancreatic Neoplasms 030104 developmental biology Ethanolamines 030220 oncology & carcinogenesis Liposomes Cancer research Dimyristoylphosphatidylcholine |
| Zdroj: | Biochemical and Biophysical Research Communications. 511:504-509 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2019.02.116 |
| Popis: | The anti-metastatic effects of cationic liposomes (CL) composed of 87 mol% dimyristoylphosphatidylcholine (DMPC), 8 mol% O,O′-ditetradecanoyl-N-(α–trimethylammonioacetyl) diethanolamine chloride (2C14ECl) and 5 mol% polyoxyethylene(21) dodecyl ether (C12(EO)21) was investigated for human pancreatic cancer (BxPC-3) cells. The inhibitory effect of CL on the migration of BxPC-3 cells was observed based on a wound scratch assay. CL suppressed pseudopodium formation of BxPC-3 cells. The anti-invasive effect of CL against BxPC-3 cells was observed via a Matrigel invasion assay. The anti-invasive effect of CL for BxPC-3 cells was found to occur through the inhibition of MMP2, MMP9, and MMP14. Overall, the results of this study revealed for the first time, the therapeutic effects and anti-metastasis activity of CL in xenograft mouse models for peritoneal metastasis of human pancreatic cancer. |
| Databáze: | OpenAIRE |
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