Pathology and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
| Autor: | Henok Kessete Afewerky |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Coronavirus disease 2019 (COVID-19) Gastrointestinal Diseases viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral Disease Virus Replication medicine.disease_cause General Biochemistry Genetics and Molecular Biology Betacoronavirus 03 medical and health sciences 0302 clinical medicine Pandemic Humans Medicine 030212 general & internal medicine Pandemics Coronavirus SARS-CoV-2 business.industry Respiratory disease virus diseases COVID-19 Virus Internalization Pathogenicity medicine.disease Virology 030104 developmental biology Viral replication Cardiovascular Diseases Minireview Nervous System Diseases Coronavirus Infections business |
| Zdroj: | Exp Biol Med (Maywood) |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.1177/1535370220942126 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta coronavirus that causes infectious respiratory disease, named as coronavirus disease of 2019 (COVID-19). While extensive studies have provided basic information on clinical characteristics of COVID-19, the disease pathology is not fully known. The SARS-CoV-2 virus structural studies and biochemical experiments have also indicated that the virus receptor-binding domain (RBD) binds with a high affinity to angiotensin-converting enzyme-2 (ACE-2) receptor from humans; however, the mechanism remains unclear. Hereunder, a summary of relevant findings in the SARS-CoV-2 virus pathology and major pathogenicity mechanisms are discussed. This review of studies provides additional enlightenments on the way forward to prevent further spread or even cure for the SARS-CoV-2 virus-caused COVID-19 disease, either-or should a similar viral plague occur in the future. Impact statement The current survey of studies outlines the direct and indirect effects of SARS-CoV-2 on the specific body systems and summarizes the SARS-CoV-2 main pathogenicity mechanisms that require attention during patient hospitalization and for further research. |
| Databáze: | OpenAIRE |
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