Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue
| Autor: | Li-li Yuan, Ren-Xiang Yv, Yin Li, Kun-Hong Liu, Guo-Yan Liu, Bing Xiong, Ji-Qin Su, Chi-Meng Tzeng, Chao Pan, Zhao‐Hui Li, Huan-Jing Zhang, Hong-Feng Liao |
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| Jazyk: | angličtina |
| Předmět: |
Normal tissue adjacent to cancer
Pathology medicine.medical_specialty Microarray lcsh:Surgery In situ hybridization Biology medicine.disease_cause lcsh:RC254-282 Metastasis Tissue microarray Genetic biomarkers Surgical oncology medicine Biomarkers Tumor Humans In Situ Hybridization Tumor microenvironment Normal tissue adjacent to benign Research lcsh:RD1-811 medicine.disease Genes p53 lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancerization Cell Transformation Neoplastic Oncology Field cancerization Surgery Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | World Journal of Surgical Oncology, Vol 10, Iss 1, p 252 (2012) World Journal of Surgical Oncology |
| ISSN: | 1477-7819 |
| DOI: | 10.1186/1477-7819-10-252 |
| Popis: | Background The histopathological and molecular heterogeneity of normal tissue adjacent to cancerous tissue (NTAC) and normal tissue adjacent to benign tissue (NTAB), and the availability of limited specimens make deciphering the mechanisms of carcinogenesis challenging. Our goal was to identify histogenetic biomarkers that could be reliably used to define a transforming fingerprint using RNA in situ hybridization. Methods We evaluated 15 tumor-related RNA in situ hybridization biomarkers using tumor microarray and samples of seven tumor-adjacent normal tissues from 314 patients. Biomarkers were determined using comprehensive statistical methods (significance of support vector machine-based artificial intelligence and area under curve scoring of classification distribution). Results TP53 was found to be a most reliable index (P -7; area under curve >87%) for distinguishing NTAC from NTAB, according to the results of a significance panel (BCL10, BECN1, BRCA2, FITH, PTCH11 and TP53). Conclusions The genetic alterations in TP53 between NTAC and NTAB may provide new insight into the field of cancerization and tumor transformation. |
| Databáze: | OpenAIRE |
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