Comparison of tissue retention of aluminum and Ga-67: effects of iron status in rats
| Autor: | Ming Min Chang, Gwendolyn M. Radzanowski, J. L. Greger |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Iron intake Anemia Iron Gallium Radioisotopes Kidney Toxicology complex mixtures Rats Sprague-Dawley Oral administration Internal medicine medicine Animals Toxicokinetics Tissue Distribution Citrates Analysis of Variance Anemia Iron-Deficiency Tibia Chemistry Spectrophotometry Atomic Kidney metabolism Metabolism medicine.disease Light metal Diet Rats Disease Models Animal Endocrinology Liver Biochemistry Iron status Spleen Aluminum |
| Zdroj: | Toxicology. 100:1-9 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(95)03030-j |
| Popis: | The purposes of this study were to separate the effect of iron status from the effect of acute iron intake on tissue retention of aluminum and Ga-67 and to evaluate Ga-67 as a marker for aluminum. Anemic and control rats were dosed by gavage with a citrate solution containing 20 microCi Ga-67 with no added aluminum and iron (Gavage Ga-67), with 0.8 mmol aluminum (Gavage Al), with 0.8 mmol iron (Gavage Fe), or with both 0.8 mmol aluminum and 0.8 mmol iron (Gavage Fe and Al). After 24 h, anemic rats in the Gavage Al treatment had lower concentrations of aluminum in their tibias, kidneys, and spleens than control rats in that treatment. In contrast, anemic rats dosed with only Ga-67 (Gavage Ga-67 treatment) had lower concentrations of Ga-67 in their tibias and kidneys, but greater concentrations of Ga-67 in their livers and spleens than control rats in that treatment. The single dose of iron had no effect on tissue aluminum concentrations but depressed tissue Ga-67 concentrations. All rats accumulated aluminum predominantly in bone and control rats accumulated Ga-67 predominantly in bone, but anemic rats accumulated Ga-67 predominantly in liver. A major limitation of Ga-67 as a marker for aluminum is its greater sensitivity than aluminum to iron intake and status. |
| Databáze: | OpenAIRE |
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